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Article

Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma.

International journal of cancer - 1 Nov 2001

Nies A T, König J, Pfannschmidt M, Klar E, Hofmann W J, Keppler D

Abstract excerpt

Treatment of hepatocellular carcinoma (HCC) by chemotherapy is often impeded by the intrinsic multidrug resistance (MDR) of this frequent primary cancer of the liver. The MDR phenotype can be caused by ATP-dependent export of chemotherapeutic drugs across the plasma membrane being mediated by transporters of the MDR P-glycoprotein family or of the multidrug resistance protein (MRP) family. To elucidate the role...

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Topics

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Share to Adenosine Triphosphate
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

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Share to Immunoblotting

Share to Microscopy, Fluorescence

Share to Multidrug Resistance-Associated Protein 2

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Source

Identifiers

PMID: 11745434
DOI: 10.1002/ijc.1498

Genes

ABCC1
ABCC2
ABCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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