Article
Variability in human hepatic MRP4 expression: influence of cholestasis and genotype.
The pharmacogenomics journal - 1 Feb 2008
Gradhand U, Lang T, Schaeffeler E, Glaeser H, Tegude H, Klein K, Fritz P, Jedlitschky G, Kroemer H K, Bachmakov I, Anwald B, Kerb R, Zanger U M, Eichelbaum M, Schwab M, Fromm M F
Abstract excerpt
The multidrug resistance protein 4 (MRP4) is an efflux transporter involved in the transport of endogenous substrates and xenobiotics. We measured MRP4 mRNA and protein expression in human livers and found a 38- and 45-fold variability, respectively. We sequenced 2 kb of the 5'-flanking region, a...
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