Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function.

Drug metabolism and pharmacokinetics - 1 Jan 2011

Sasaki Tomohiro, Hirota Takeshi, Ryokai Yuriko, Kobayashi Daisuke, Kimura Miyuki, Irie Shin, Higuchi Shun, Ieiri Ichiro

Abstract excerpt

The present study was undertaken to identify genetic polymorphisms of multidrug resistance-associated protein 3 (MRP3, gene name ABCC3), an ATP-binding cassette transporter that mediates the transport of substrates across the basolateral membrane into the blood, and to investigate their effects on ABCC3 expression and MRP3 function. We identified genetic polymorphisms of ABCC3 and evaluated the effects by (1) a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Gene Amplification

Share to Genes, Reporter

Share to Luciferases

Share to Multidrug Resistance-Associated Proteins

Share to White People

Source

Identifiers

PMID: 21512263
DOI: 10.2133/dmpk.dmpk-10-rg-103

Genes

ABCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function.PMID 21512263Read ↗

Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)Semantic proximity Read ↗

Genetic variations of the ABC transporter gene ABCC3 in a Japanese population.Semantic proximity Read ↗

Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver.Semantic proximity Read ↗

Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.Semantic proximity Read ↗

The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.Semantic proximity Read ↗

Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application.Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding?Semantic proximity Read ↗

Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.Semantic proximity Read ↗

Genetic variations of the ABCC2 gene in the Chinese, Malay, and Indian populations of Singapore.Semantic proximity Read ↗

Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression.Semantic proximity Read ↗

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.