Article
Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: comparison with spontaneously hypertensive rats.
Physiological genomics - 8 Jul 2004
Siegel Anja-Kristin, Kossmehl Peter, Planert Michael, Schulz Angela, Wehland Markus, Stoll Monika, Bruijn Jan A, de Heer Emile, Kreutz Reinhold
Abstract excerpt
Our aim was to study the effects of high-salt diet on the genetics of albuminuria and renal injury in the Dahl salt-sensitive (SS) rat. We compared SS with salt-resistant spontaneously hypertensive rats (SHR) and with genetically related salt-sensitive stroke-prone SHR (SHRSP). Moreover, we performed genome-wide linkage analysis to identify quantitative trait loci (QTL) contributing to salt-induced renal injury...
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