Article
Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats.
Physiological genomics - 11 Nov 2003
Moreno Carol, Dumas Pierre, Kaldunski Mary L, Tonellato Peter J, Greene Andrew S, Roman Richard J, Cheng Qunli, Wang Zhitao, Jacob Howard J, Cowley Allen W
Abstract excerpt
Genetic linkage analyses in human populations have traditionally combined male and female progeny for determination of quantitative trait loci (QTL). In contrast, most rodent studies have focused primarily on males. This study represents an extensive female-specific linkage analysis in which 236 neuroendocrine, renal, and cardiovascular traits related to arterial pressure (BP) were determined in 99 female F2 rats...
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