Article
Genetic analysis of salt-sensitive hypertension in Dahl rats reveals a link between cardiac fibrosis and high cholesterol.
Cardiovascular research - 15 Feb 2009
Wendt Norbert, Schulz Angela, Qadri Fatimunnisa, Bolbrinker Juliane, Kossmehl Peter, Winkler Karl, Stoll Monika, Vetter Roland, Kreutz Reinhold
Abstract excerpt
AIMS: Previously we confirmed an important role of rat chromosome 19 (RNO19) for salt-sensitive hypertension and target organ damage in male Dahl salt-sensitive rats (SS rats). The aim of this study was to further analyse the basis of left ventricular (LV) fibrosis development in both male and female rats in this model. To this end we utilized a consomic SS-19(SHR) rat strain in which RNO19 was transferred from...
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