Article
Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet.
Journal of the American Society of Nephrology : JASN - 1 May 2003
Garrett Michael R, Dene Howard, Rapp John P
Abstract excerpt
The Dahl salt-sensitive hypertensive (S) rat develops albuminuria early in life even on a low-salt diet. In contrast, the spontaneously hypertensive rat (SHR) is highly resistant to developing albuminuria despite elevated BP. An F(1) hybrid of S and SHR showed a low urinary albumin excretion (UAE) and low urinary protein excretion (UPE) similar to SHR, i.e., SHR was dominant. A genetic analysis was carried out on...
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