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Article

Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background.

Physiological genomics - 15 Jun 2012

Regner Kevin R, Harmon Ashlyn C, Williams Jan M, Stelloh Cary, Johnson Ashley C, Kyle Patrick B, Lerch-Gaggl Alexandra, White Sarah M, Garrett Michael R

Abstract excerpt

The Dahl salt-sensitive (S) rat is a widely studied model of salt-sensitive hypertension and develops proteinuria, glomerulosclerosis, and renal interstitial fibrosis. An earlier genetic analysis using a population derived from the S and spontaneously hypertensive rat (SHR) identified eight genomic regions linked to renal injury in the S rat and one protective locus on chromosome 11. The "protective" locus in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22548739
DOI: 10.1152/physiolgenomics.00015.2012
PMCID: PMC3426430

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