Article
Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loading.
Physiological genomics - 15 Aug 2003
Poyan Mehr Ali, Siegel Anja-Kristin, Kossmehl Peter, Schulz Angela, Plehm Ralph, de Bruijn Jan A, de Heer Emile, Kreutz Reinhold
Abstract excerpt
The aim of the study was to characterize the genetic basis for the early onset of increased urinary albumin excretion (UAE) observed in the salt-sensitive Dahl rat (SS). We first characterized blood pressures and UAE values in adult SS compared with the spontaneously hypertensive rat (SHR) strain. Blood pressure measurements by radiotelemetry at 14 wk demonstrated similar spontaneous hypertension in both strains...
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