Article
Genetic loci contribute to the progression of vascular and cardiac hypertrophy in salt-sensitive spontaneous hypertension.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2003
Siegel Anja-Kristin, Planert Michael, Rademacher Sibylle, Mehr Ali Poyan, Kossmehl Peter, Wehland Markus, Stoll Monika, Kreutz Reinhold
Abstract excerpt
OBJECTIVE: The salt-sensitive Dahl rat and the spontaneously hypertensive rat develop comparable spontaneous hypertension on a low-salt diet, whereas only the salt-sensitive Dahl rat strain develops a striking increase in blood pressure and cardiovascular hypertrophy on a high-salt diet. We set out to identify quantitative trait loci (QTLs) contributing to the progression of salt-induced organ damage in...
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