Article
Genetically defined risk of salt sensitivity in an intercross of Brown Norway and Dahl S rats.
Physiological genomics - 27 Apr 2000
Cowley A W, Stoll M, Greene A S, Kaldunski M L, Roman R J, Tonellato P J, Schork N J, Dumas P, Jacob H J
Abstract excerpt
A genetic segregation analysis was performed to identify genes that cosegregate with arterial blood pressure traits reflective of salt sensitivity. A population of 113 F2 male rats was derived from an intercross of inbred SS/JrHsd/Mcw (Dahl salt-sensitive) and BN/SsN/Mcw (Brown Norway) rats. Rats were maintained on an 8% salt diet from the age of 9 to 13 wk, and arterial pressure was measured for 3 h daily during...
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