Article
Importance sampling method of correction for multiple testing in affected sib-pair linkage analysis.
BMC genetics - 31 Dec 2003
Klein Alison P, Kovac Ilija, Sorant Alexa J M, Baffoe-Bonnie Agnes, Doan Betty Q, Ibay Grace, Lockwood Erica, Mandal Diptasri, Santhosh Lekshmi, Weissbecker Karen, Woo Jessica, Zambelli-Weiner April, Zhang Jie, Naiman Daniel Q, Malley James, Bailey-Wilson Joan E
Abstract excerpt
Using the Genetic Analysis Workshop 13 simulated data set, we compared the technique of importance sampling to several other methods designed to adjust p-values for multiple testing: the Bonferroni correction, the method proposed by Feingold et al., and naïve Monte Carlo simulation. We performed...
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