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Article

Weighting affected sib pairs by marker informativity.

American journal of human genetics - 1 Aug 2005

Franke Daniel, Ziegler Andreas

Abstract excerpt

For the analysis of affected sib pairs (ASPs), a variety of test statistics is applied in genomewide scans with microsatellite markers. Even in multipoint analyses, these statistics might not fully exploit the power of a given sample, because they do not account for incomplete informativity of an ASP. For meta-analyses of linkage and association studies, it has been shown recently that weighting by informativity...

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Identifiers

PMID: 15986318
DOI: 10.1086/432378
PMCID: PMC1224526

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