Article
Using identity-by-descent information in affected sib pairs to increase the efficiency of genetic association studies.
Twin research : the official journal of the International Society for Twin Studies - 1 Apr 2004
Wicks Jacqueline, Treloar Susan A, Martin Nicholas G
Abstract excerpt
The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive,...
Topics
- Alleles
- Case-Control Studies
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Lod Score
- Models, Genetic
- Outcome Assessment, Health Care
- Siblings