Optimal weighting scheme for affected sib-pair analysis of sibship data.

doi:10.1046/j.1469-1809.1997.6110059.x

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Article

Optimal weighting scheme for affected sib-pair analysis of sibship data.

Annals of human genetics - 1 Jan 1997

Sham P C, Zhao J H, Curtis D

Abstract excerpt

Application of the affected sib-pair method of linkage analysis to sibships with variable numbers of affected and unaffected members requires a scheme for weighting the contributions from the sibships in the calculation of an overall test statistic. Currently accepted weighting schemes are based...

Topics

Alleles
Gene Frequency
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genotype
Humans
Models, Genetic
Models, Statistical
Nuclear Family
Pedigree

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