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Article

Statistical properties of affected sib-pair linkage tests.

Human heredity - 1 Jan 2003

Wu Chih-Chieh, Amos Christopher I

Abstract excerpt

Genetic linkage analysis is a powerful tool for the identification of disease susceptibility loci. Among the most commonly applied genetic linkage strategies are affected sib-pair tests, but the statistical properties of these tests have not been well characterized. Here, we present a study of the distribution of affected sib-pair tests comparing the type I error rate and the power of the mean test and the...

Topics

Alleles
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Humans
Likelihood Functions
Matched-Pair Analysis
Models, Genetic
Models, Statistical
Siblings

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PMID: 14566093
DOI: 10.1159/000073199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14566093-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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