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Article

Affected kin-pair IBD methods: genetic models.

Genetic epidemiology - 1 Jan 1991

Motro U, Thomson G

Abstract excerpt

Cases of interest using affected sib-pair methods to distinguish between recessive and additive (dominant) modes of inheritance of a disease-predisposing gene involve goodness-of-fit tests with a small expected number in the "share-zero parental haplotypes" category, as well as an unknown parameter, the frequency of the disease-predisposing allele. Our simulations demonstrate that the real significance level of...

Topics

Alleles
Chi-Square Distribution
Gene Frequency
Genes, Recessive
Genetic Diseases, Inborn
Haplotypes
Humans
Models, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1761204
DOI: 10.1002/gepi.1370080504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1761204-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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