Article
Nonparametric tests for linkage with dependent sib pairs.
Human heredity - 1 Jan 2000
Collins A, Morton N E
Abstract excerpt
Sib pair tests for linkage to a quantitative trait or affection status are examined by simulation. A sibship of size s contributes only s-1 independent sib pairs but all s(s-1)/2 pairs are needed for an efficient test. Redundancy increases with sibship size. Using simulated data on the null hypothesis of no linkage, we have considered equal and unequal weights. Unequal weights lose power as measured by the...
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