Association tests using unaffected-sibling versus pseudo-sibling controls.

doi:10.1002/gepi.13701707120

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Article

Association tests using unaffected-sibling versus pseudo-sibling controls.

Genetic epidemiology - 1 Jan 1999

Siegmund K D, Gauderman W J, Thomas D C

Abstract excerpt

We used family-matched case-control data to screen the genome for markers associated with disease in the simulated data set. Two different types of controls were considered: (1) unaffected siblings and (2) 'pseudo siblings,' a comparison sample created using the parental alleles. The scans were c...

Topics

Alleles
Genetic Linkage
Genetic Markers
Genetic Testing
Genome
Genotype
Likelihood Functions
Linkage Disequilibrium
Models, Genetic
Models, Statistical
Nuclear Family

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