Article
Association tests using unaffected-sibling versus pseudo-sibling controls.
Genetic epidemiology - 1 Jan 1999
Siegmund K D, Gauderman W J, Thomas D C
Abstract excerpt
We used family-matched case-control data to screen the genome for markers associated with disease in the simulated data set. Two different types of controls were considered: (1) unaffected siblings and (2) 'pseudo siblings,' a comparison sample created using the parental alleles. The scans were conducted on the first replicate of each study population. Overall, the two methods identified 14 marker loci associated...
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