Correcting for ascertainment bias of relative-risk estimates obtained using affected-sib-pair linkage data.

doi:10.1002/(SICI)1098-2272(200004)18:4<307::AID-GEPI4>3.0.CO;2-3

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Article

Correcting for ascertainment bias of relative-risk estimates obtained using affected-sib-pair linkage data.

Genetic epidemiology - 1 Apr 2000

Cordell H J, Olson J M

Abstract excerpt

Locus-specific sibling relative risk is often estimated using affected-sib-pair lod score analysis of affected sibships and may be used to decide whether to continue or discontinue the search for additional susceptibility genes. We showed that relative-risk estimates obtained using affected-sib-p...

Topics

Bias
Computer Simulation
Genetic Diseases, Inborn
Genetic Linkage
Genetic Predisposition to Disease
Humans
Likelihood Functions
Models, Genetic
Models, Statistical
Nuclear Family
Pedigree
Penetrance
Risk
Twins, Monozygotic

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