Affected sib-pair tests for linkage: type I errors with dependent sib-pairs.

doi:10.1002/(SICI)1098-2272(1997)14:6<1107::AID-GEPI91>3.0.CO;2-K

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Article

Affected sib-pair tests for linkage: type I errors with dependent sib-pairs.

Genetic epidemiology - 1 Jan 1997

Meunier F, Philippi A, Martinez M, Demenais F

Abstract excerpt

We compared the robustness of affected-sib-pair (ASP) tests for multiple-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrease the efficiency of the tests. Another weighting procedure accounting for the reductio...

Topics

Age of Onset
Analysis of Variance
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genotype
Heterozygote
Humans
Male
Matched-Pair Analysis
Monte Carlo Method
Nuclear Family
Predictive Value of Tests

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