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Article

Affected sib-pair tests for linkage: type I errors with dependent sib-pairs.

Genetic epidemiology - 1 Jan 1997

Meunier F, Philippi A, Martinez M, Demenais F

Abstract excerpt

We compared the robustness of affected-sib-pair (ASP) tests for multiple-affected sibships. Forming all possible pairs increases the type I errors only slightly whereas the most used weighting procedures decrease the efficiency of the tests. Another weighting procedure accounting for the reduction of variance of the weighted identical by descent (IBD) information appears robust. Missing parental marker data leads...

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Identifiers

PMID: 9433632
DOI: 10.1002/(SICI)1098-2272(1997)14:6<1107::AID-GEPI91>3.0.CO;2-K

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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