Effects of vaccine strain mutations in domain V of the internal ribosome entry segment compared in the wild type poliovirus type 1 context.

doi:10.1074/jbc.M307806200

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Effects of vaccine strain mutations in domain V of the internal ribosome entry segment compared in the wild type poliovirus type 1 context.

The Journal of biological chemistry - 12 Mar 2004

Malnou Cécile E, Werner Andreas, Borman Andrew M, Westhof Eric, Kean Katherine M

Abstract excerpt

Initiation of poliovirus (PV) protein synthesis is governed by an internal ribosome entry segment structured into several domains including domain V, which is accepted to be important in PV neurovirulence because it harbors an attenuating mutation in each of the vaccine strains developed by A. Sa...

Topics

Base Sequence
Blotting, Western
DNA, Viral
Electrophoresis, Polyacrylamide Gel
Eukaryotic Initiation Factor-4G
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Neuroblastoma
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasmids

Point Mutation

Poliovirus

Poliovirus Vaccines

Protein Biosynthesis

Protein Isoforms

Source

Open in PubMed

Identifiers

PMID: 14672927
DOI: 10.1074/jbc.M307806200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-14672927-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of vaccine strain mutations in domain V of the internal ribosome entry segment compared in the wild type poliovirus type 1 context.PMID 14672927Read ↗

Effects of the Sabin-like mutations in domain V of the internal ribosome entry segment on translational efficiency of the Coxsackievirus B3.Semantic proximity Read ↗

Molecular mechanism of poliovirus Sabin vaccine strain attenuation.Semantic proximity Read ↗

Characterization of in vitro and in vivo phenotypes of poliovirus type 1 mutants with reduced viral protein synthesis activity.Semantic proximity Read ↗

Poliovirus internal ribosome entry segment structure alterations that specifically affect function in neuronal cells: molecular genetic analysis.Semantic proximity Read ↗

The substitution U475 --> C with Sabin3-like mutation within the IRES attenuate Coxsackievirus B3 cardiovirulence.Semantic proximity Read ↗

Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms.Semantic proximity Read ↗

Mapping of mutations contributing to the temperature sensitivity of the Sabin 1 vaccine strain of poliovirus.Semantic proximity Read ↗

Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.Semantic proximity Read ↗

A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.Semantic proximity Read ↗

Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence.Semantic proximity Read ↗

Attenuation stem-loop lesions in the 5' noncoding region of poliovirus RNA: neuronal cell-specific translation defects.Semantic proximity Read ↗

Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.