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Article

Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence.

Journal of virology - 1 Nov 2005

De Jesus Nidia, Franco David, Paul Aniko, Wimmer Eckard, Cello Jeronimo

Abstract excerpt

The chemical synthesis of poliovirus (PV) cDNA combined with the cell-free synthesis of infectious particles yielded virus whose mouse neurovirulence was highly attenuated (J. Cello, A. V. Paul, and E. Wimmer, Science 297:1016-1018, 2002). Compared to the wild-type PV1 (Mahoney) [PV1(M)] sequence, the synthetic virus genome harbored 27 nucleotide (nt) changes deliberately introduced as genetic markers. Of the 27...

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Identifiers

PMID: 16254358
DOI: 10.1128/JVI.79.22.14235-14243.2005
PMCID: PMC1280220

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