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Article

Mapping of mutations contributing to the temperature sensitivity of the Sabin 1 vaccine strain of poliovirus.

Journal of virology - 1 Sept 1995

Georgescu M M, Tardy-Panit M, Guillot S, Crainic R, Delpeyroux F

Abstract excerpt

The temperature-sensitive and attenuated phenotypes of the Sabin type 1 vaccine strain of poliovirus result from numerous point mutations which occurred in the virulent Mahoney virus parent. One of these mutations is located in a 3D polymerase (3Dpol) codon (U-6203-->C, Tyr-73-->His) and is involved in attenuation in common mice (M. Tardy-Panit, B. Blondel, A. Martin, F. Tekaia, F. Horaud, and F. Delpeyroux, J....

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Identifiers

PMID: 7636970
DOI: 10.1128/JVI.69.9.5278-5286.1995
PMCID: PMC189363

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