Attenuation stem-loop lesions in the 5' noncoding region of poliovirus RNA: neuronal cell-specific translation defects.

doi:10.1128/JVI.70.3.1467-1474.1996

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Article

Attenuation stem-loop lesions in the 5' noncoding region of poliovirus RNA: neuronal cell-specific translation defects.

Journal of virology - 1 Mar 1996

Haller A A, Stewart S R, Semler B L

Abstract excerpt

The nucleotide at position 480 in the 5' noncoding region of the viral RNA genome plays an important role in directing the attenuation phenotype of the Sabin vaccine strain of poliovirus type 1. In vitro translation studies have shown that the attenuated viral genomes of the Sabin strains direct...

Topics

Base Sequence
Defective Viruses
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Neurons
Nucleic Acid Conformation
Poliovirus
Protein Biosynthesis
RNA, Viral
Tumor Cells, Cultured
Viral Proteins

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