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Article

Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3.

Journal of virology - 1 Oct 2004

Guest Stephen, Pilipenko Evgeny, Sharma Kamal, Chumakov Konstantin, Roos Raymond P

Abstract excerpt

Mutations critical for the central nervous system (CNS) attenuation of the Sabin vaccine strains of poliovirus (PV) are located within the viral internal ribosome entry site (IRES). We examined the interaction of the IRESs of PV type 3 (PV3) and Sabin type 3 (Sabin3) with polypyrimidine tract-binding protein (PTB) and a neural cell-specific homologue, nPTB. PTB and nPTB were found to bind to a site directly...

Topics

Animals
Binding Sites
Cell Line
Chick Embryo
Cricetinae
Electroporation
HeLa Cells
Humans
Mutation
Neurons
Poliovirus
Poliovirus Vaccine, Oral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polypyrimidine Tract-Binding Protein

Protein Biosynthesis

Ribosomes

Spinal Cord

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 15452230
DOI: 10.1128/JVI.78.20.11097-11107.2004
PMCID: PMC521805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15452230-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3.PMID 15452230Read ↗

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