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Article

Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.

Journal of virology - 1 Dec 1995

McGoldrick A, Macadam A J, Dunn G, Rowe A, Burlison J, Minor P D, Meredith J, Evans D J, Almond J W

Abstract excerpt

Of the 55 point mutations which distinguish the type 1 poliovirus vaccine strain (Sabin 1) from its neurovirulent progenitor (P1/Mahoney), two have been strongly implicated by previous studies as determinants of the attenuation phenotype. A change of an A to a G at position 480, located within the 5' noncoding region, has been suggested to be the major attenuating mutation, analogous to the mutations at positions...

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Identifiers

PMID: 7494267
DOI: 10.1128/JVI.69.12.7601-7605.1995
PMCID: PMC189699

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.PMID 7494267Read ↗

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