Article
Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.
Journal of virology - 1 Dec 1995
McGoldrick A, Macadam A J, Dunn G, Rowe A, Burlison J, Minor P D, Meredith J, Evans D J, Almond J W
Abstract excerpt
Of the 55 point mutations which distinguish the type 1 poliovirus vaccine strain (Sabin 1) from its neurovirulent progenitor (P1/Mahoney), two have been strongly implicated by previous studies as determinants of the attenuation phenotype. A change of an A to a G at position 480, located within the 5' noncoding region, has been suggested to be the major attenuating mutation, analogous to the mutations at positions...
Topics
- Cell Line
- Cloning, Molecular
- Cytosine
- DNA, Complementary
- Genome, Viral
- Guanine
- Humans
- Nucleic Acid Conformation
- Phenotype
- Point Mutation
- Poliovirus