Article
Poliovirus internal ribosome entry segment structure alterations that specifically affect function in neuronal cells: molecular genetic analysis.
Journal of virology - 1 Nov 2002
Malnou Cécile E, Pöyry Tuija A A, Jackson Richard J, Kean Katherine M
Abstract excerpt
Translation of poliovirus RNA is driven by an internal ribosome entry segment (IRES) present in the 5' noncoding region of the genomic RNA. This IRES is structured into several domains, including domain V, which contains a large lateral bulge-loop whose predicted secondary structure is unclear. The primary sequence of this bulge-loop is strongly conserved within enteroviruses and rhinoviruses: it encompasses two...
Topics
- Amino Acid Motifs
- Base Sequence
- Defective Viruses
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutagenesis
- Neuroblastoma
- Neurons
- Nucleic Acid Conformation
- Phenotype
- Poliovirus
- Protein Biosynthesis
- RNA, Viral