Article
Effects of the Sabin-like mutations in domain V of the internal ribosome entry segment on translational efficiency of the Coxsackievirus B3.
Molecular genetics and genomics : MGG - 1 Oct 2006
Ben M'hadheb-Gharbi Manel, Gharbi Jawhar, Paulous Sylvie, Brocard Michèle, Komaromva Anastasia, Aouni Mahjoub, Kean Katherine M
Abstract excerpt
The domain V within the internal ribosome entry segment (IRES) of poliovirus (PV) is expected to be important in its own neurovirulence because it contains an attenuating mutation in each of the Sabin vaccine strains. In this study, we try to find out if the results observed in the case of Sabin...
Topics
- Animals
- Base Sequence
- DNA, Viral
- Enterovirus B, Human
- HeLa Cells
- Humans
- In Vitro Techniques
- Mutagenesis, Site-Directed
- Mutation
- Nucleic Acid Conformation
- Poliovirus
- Poliovirus Vaccine, Oral
- Protein Biosynthesis
- RNA, Ribosomal