Molecular mechanism of poliovirus Sabin vaccine strain attenuation.

doi:10.1074/jbc.RA118.004913

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Article

Molecular mechanism of poliovirus Sabin vaccine strain attenuation.

The Journal of biological chemistry - 5 Oct 2018

Avanzino Brian C, Jue Helen, Miller Clare M, Cheung Emily, Fuchs Gabriele, Fraser Christopher S

Abstract excerpt

Recruitment of poliovirus (PV) RNA to the human ribosome requires the coordinated interaction of the viral internal ribosome entry site (IRES) and several host cellular initiation factors and IRES trans-acting factors (ITAFs). Attenuated PV Sabin strains contain point mutations in the PV IRES domain V (dV) that inhibit viral translation. Remarkably, attenuation is most apparent in cells of the central nervous...

Topics

Animals
Baculoviridae
Base Sequence
Cloning, Molecular
Escherichia coli
Eukaryotic Initiation Factor-4A
Eukaryotic Initiation Factor-4G
Gene Expression
Genes, Reporter
Genetic Vectors
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Internal Ribosome Entry Sites

Luciferases

Mutation

Nucleic Acid Conformation

Poliovirus

Poliovirus Vaccine, Oral

Source

Open in PubMed Open full text

Identifiers

PMID: 30126841
DOI: 10.1074/jbc.RA118.004913
PMCID: PMC6177584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-30126841-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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