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Article

Molecular mechanism of poliovirus Sabin vaccine strain attenuation.

The Journal of biological chemistry - 5 Oct 2018

Avanzino Brian C, Jue Helen, Miller Clare M, Cheung Emily, Fuchs Gabriele, Fraser Christopher S

Abstract excerpt

Recruitment of poliovirus (PV) RNA to the human ribosome requires the coordinated interaction of the viral internal ribosome entry site (IRES) and several host cellular initiation factors and IRES trans-acting factors (ITAFs). Attenuated PV Sabin strains contain point mutations in the PV IRES domain V (dV) that inhibit viral translation. Remarkably, attenuation is most apparent in cells of the central nervous...

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PMID: 30126841
DOI: 10.1074/jbc.RA118.004913
PMCID: PMC6177584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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