Characterization of in vitro and in vivo phenotypes of poliovirus type 1 mutants with reduced viral protein synthesis activity.

doi:10.1099/vir.0.19768-0

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Article

Characterization of in vitro and in vivo phenotypes of poliovirus type 1 mutants with reduced viral protein synthesis activity.

The Journal of general virology - 1 Jul 2004

Arita Minetaro, Shimizu Hiroyuki, Miyamura Tatsuo

Abstract excerpt

Sabin vaccine strains of poliovirus (PV) contain major attenuation determinants in the internal ribosomal entry site (IRES), an area that directs viral protein synthesis. To examine the effect of reduced viral protein synthesis on PV neurovirulence, spacer sequences, consisting of short open read...

Topics

Animals
Base Sequence
Calorimetry
Cell Line, Tumor
DNA Primers
HeLa Cells
Humans
Mice
Mice, Transgenic
Models, Molecular
Molecular Sequence Data
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Phenotype

Poliovirus

Protein Biosynthesis

RNA, Viral

Replicon

Source

Open in PubMed

Identifiers

PMID: 15218178
DOI: 10.1099/vir.0.19768-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15218178-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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