A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.

doi:10.1128/JVI.66.5.3194-3197.1992

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Article

A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.

Journal of virology - 1 May 1992

Tatem J M, Weeks-Levy C, Georgiu A, DiMichele S J, Gorgacz E J, Racaniello V R, Cano F R, Mento S J

Abstract excerpt

The attenuated phenotype of Sabin 3 poliovirus compared with its neurovirulent progenitor strain has been largely accounted for by mutations in the genome at positions 472 and 2034 (G. D. Westrop, K. A. Wareham, D. M. A. Evans, G. Dunn, P. D. Minor, D. I. Magrath, F. Taffs, S. Marsden, M. A. Skin...

Topics

Animals
Capsid
Capsid Proteins
Mutation
Phenotype
Poliomyelitis
Poliovirus
Vaccines, Attenuated
Vero Cells

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