Article
Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms.
Diagnostic pathology - 24 Sept 2013
Souii Amira, Gharbi Jawhar, Ben M'hadheb-Gharbi Manel
Abstract excerpt
Internal ribosome entry site (IRES) elements fold into highly organized conserved secondary and probably tertiary structures that guide the ribosome to an internal site of the RNA at the IRES 3'end. The composition of the cellular proteome is under the control of multiple processes, one of the mo...
Topics
- 5' Untranslated Regions
- Animals
- Binding Sites
- Cloning, Molecular
- Cricetinae
- Enterovirus B, Human
- Eukaryotic Initiation Factor-3
- Eukaryotic Initiation Factor-4G
- Eukaryotic Initiation Factors
- HeLa Cells
- Humans
- Molecular Weight
- Mutagenesis, Site-Directed
- Mutation