Article
The substitution U475 --> C with Sabin3-like mutation within the IRES attenuate Coxsackievirus B3 cardiovirulence.
Molecular biotechnology - 1 May 2007
M'hadheb-Gharbi Manel Ben, Paulous Sylvie, Aouni Mahjoub, Kean Katherine M, Gharbi Jawhar
Abstract excerpt
The Sabin3 mutation in the viral RNA plays an important role in directing attenuation phenotype of Sabin vaccine strain of poliovirus type 1 (PV1). We previously described that Sabin3-like mutation introduced in Coxsackievirus B3 (CVB3) genome led to a defective mutant. However, this mutation do not led to destruction of secondary structure motif C within the stem-loop V of CVB3 RNA because of the presence of one...
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