Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis on origin recognition complex containing Orc5p with defective Walker A motif.

The Journal of biological chemistry - 27 Feb 2004

Takahashi Naoko, Yamaguchi Yoshihiro, Yamairi Fumiko, Makise Masaki, Takenaka Hitomi, Tsuchiya Tomofusa, Mizushima Tohru

Abstract excerpt

Orc5p is one of six proteins that make up the origin recognition complex (ORC), a candidate initiator of chromosomal DNA replication in eukaryotes. To investigate the role of ATP binding to Orc5p in cells, we constructed orc5-A, a strain of Saccharomyces cerevisiae having a mutation in the Walker A motif of Orc5p (K43E). The strain showed temperature-sensitive growth. Incubation at a nonpermissive temperature (37...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Drug Stability

Share to Gene Library

Share to Genes, Suppressor

Share to Immunoblotting

Share to Origin Recognition Complex

Source

Identifiers

PMID: 14625297
DOI: 10.1074/jbc.M305531200

Genes

ORC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis on origin recognition complex containing Orc5p with defective Walker A motif.PMID 14625297Read ↗

Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.Semantic proximity Read ↗

Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro.Semantic proximity Read ↗

Kinetics of ATP binding to the origin recognition complex of Saccharomyces cerevisiae.Semantic proximity Read ↗

The origin recognition complex in silencing, cell cycle progression, and DNA replication.Semantic proximity Read ↗

Analysis of origin recognition complex in saccharomyces cerevisiae by use of Degron mutants.Semantic proximity Read ↗

ATP bound to the origin recognition complex is important for preRC formation.Semantic proximity Read ↗

Studies of the properties of human origin recognition complex and its Walker A motif mutants.Semantic proximity Read ↗

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Semantic proximity Read ↗

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.