Article
Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.
The Biochemical journal - 1 Mar 2007
Makise Masaki, Takahashi Naoko, Matsuda Kazuya, Yamairi Fumiko, Suzuki Keitarou, Tsuchiya Tomofusa, Mizushima Tohru
Abstract excerpt
Orc5p is one of six subunits constituting the ORC (origin recognition complex), a possible initiator of chromosomal DNA replication in eukaryotes. Orc5p contains a Walker A motif. We recently reported that a strain of Saccharomyces cerevisiae having a mutation in Orc5p's Walker A motif (orc5-A), showed cell-cycle arrest at G2/M and degradation of ORC at high temperatures (37 degrees C). Over-production of Orc4p,...
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