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Article

Analysis of origin recognition complex in saccharomyces cerevisiae by use of Degron mutants.

Journal of biochemistry - 1 Apr 2008

Makise Masaki, Matsui Nanako, Yamairi Fumiko, Takahashi Naoko, Takehara Masaya, Asano Teita, Mizushima Tohru

Abstract excerpt

Origin recognition complex (ORC), a six-protein complex (Orc1p-Orc6p), may deeply involve in initiation of chromosomal DNA replication. However, since most temperature-sensitive orc mutants of Saccharomyces cerevisiae show the accumulation of cells with nearly 2C DNA content, the exact stage at which ORC acts is not fully understood. In this study, we constructed a heat-inducible degron mutant for each ORC...

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Identifiers

PMID: 18211918
DOI: 10.1093/jb/mvn005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Analysis of origin recognition complex in saccharomyces cerevisiae by use of Degron mutants.PMID 18211918Read ↗

Involvement of RAD9-dependent damage checkpoint control in arrest of cell cycle, induction of cell death, and chromosome instability caused by defects in origin recognition complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis on origin recognition complex containing Orc5p with defective Walker A motif.Semantic proximity Read ↗

Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro.Semantic proximity Read ↗

Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Yeast origin recognition complex functions in transcription silencing and DNA replication.Semantic proximity Read ↗

The origin recognition complex is dispensable for endoreplication in Drosophila.Semantic proximity Read ↗

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.Semantic proximity Read ↗

ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.Semantic proximity Read ↗

Orc mutants arrest in metaphase with abnormally condensed chromosomes.Semantic proximity Read ↗

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