Article
Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.
Cell cycle (Georgetown, Tex.) - 15 Apr 2008
Kato Hiroaki, Matsunaga Fujihiko, Miyazaki Shota, Yin Ling, D'Urso Gennaro, Tanaka Katsunori, Murakami Yota
Abstract excerpt
The six-subunit origin recognition complex (ORC) acts as a landing pad for factors that initiate DNA replication by binding to replication origins. In addition, ORC is involved in other processes such as transcriptional gene silencing and sister chromatid cohesion in Saccharomyces cerevisiae. However, whether these functions of ORC are specific to Saccharomyces cerevisiae or are shared by the ORC of other...
Topics
- Cell Cycle
- Chromatids
- Chromatin Immunoprecipitation
- DNA Replication
- Genomic Instability
- Mutation
- Origin Recognition Complex
- Schizosaccharomyces
- Species Specificity