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Article

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.

Genetics - 1 Nov 1997

Dillin A, Rine J

Abstract excerpt

Origin recognition complex (ORC) is a six subunit complex that functions as the replication initiator and is required for silencing the HML and HMR loci in the yeast Saccharomyces cerevisiae. The roles of ORC5 in replication initiation and silencing were investigated to determine whether the two roles were mechanistically coincident or separable. Some spontaneous revertants of orc5-1 were functional for...

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Source

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Identifiers

PMID: 9383052
DOI: 10.1093/genetics/147.3.1053
PMCID: PMC1208233

Genes

ORC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.PMID 9383052Read ↗

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.Semantic proximity Read ↗

Separation of origin recognition complex functions by cross-species complementation.Semantic proximity Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

The origin recognition complex in silencing, cell cycle progression, and DNA replication.Semantic proximity Read ↗

Two compound replication origins in Saccharomyces cerevisiae contain redundant origin recognition complex binding sites.Semantic proximity Read ↗

Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.Semantic proximity Read ↗

A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.Semantic proximity Read ↗

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.Semantic proximity Read ↗

The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast.Semantic proximity Read ↗

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