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Article

ATP bound to the origin recognition complex is important for preRC formation.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jul 2001

Klemm R D, Bell S P

Abstract excerpt

The origin recognition complex (ORC) binds origins of replication and directs the assembly of a higher order protein complex at these sites. ORC binds and hydrolyzes ATP in vitro. ATP binding to the largest subunit of ORC, Orc1p, stimulates specific binding to origin DNA; however, the function of ATP hydrolysis by ORC is unknown. To address the role of ATP hydrolysis, we have generated mutants within Orc1p that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11459976
DOI: 10.1073/pnas.131006898
PMCID: PMC37444

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Source receipt: pubmed, retrieved 7 Sept 2026.

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ATP bound to the origin recognition complex is important for preRC formation.PMID 11459976Read ↗

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The origin recognition complex in silencing, cell cycle progression, and DNA replication.Semantic proximity Read ↗

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Studies of the properties of human origin recognition complex and its Walker A motif mutants.Semantic proximity Read ↗

Analysis on origin recognition complex containing Orc5p with defective Walker A motif.Semantic proximity Read ↗

Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.Semantic proximity Read ↗

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