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Article

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.

Genes & development - 15 Apr 1995

Fox C A, Loo S, Dillin A, Rine J

Abstract excerpt

The role of the origin recognition complex (ORC) was investigated in replication initiation and in silencing. Temperature-sensitive mutations in ORC genes caused defects in replication initiation at chromosomal origins of replication, as measured by two-dimensional (2-D) origin-mapping gels, fork migration analysis, and plasmid replication studies. These data were consistent with ORC functioning as a eukaryotic...

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Source

Identifiers

PMID: 7774809
DOI: 10.1101/gad.9.8.911

Genes

ORC5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.PMID 7774809Read ↗

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Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.Semantic proximity Read ↗

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Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

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The origin recognition complex is dispensable for endoreplication in Drosophila.Semantic proximity Read ↗

Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences.Semantic proximity Read ↗

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ORC1 binds to <i>cis</i> -transcribed RNAs for efficient activation of replication originsSemantic proximity Read ↗

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