Article
The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.
Genes & development - 15 Apr 1995
Fox C A, Loo S, Dillin A, Rine J
Abstract excerpt
The role of the origin recognition complex (ORC) was investigated in replication initiation and in silencing. Temperature-sensitive mutations in ORC genes caused defects in replication initiation at chromosomal origins of replication, as measured by two-dimensional (2-D) origin-mapping gels, fork...
Topics
- Cell Cycle
- Chromosomes, Fungal
- DNA Replication
- DNA, Fungal
- DNA-Binding Proteins
- Eukaryotic Cells
- Fungal Proteins
- Genes, Fungal
- Mutation
- Nucleic Acid Conformation
- Origin Recognition Complex
- Plasmids
- Replication Origin
- Repressor Proteins
- Saccharomyces cerevisiae Proteins
- Transcription, Genetic
- Yeasts