The origin recognition complex in silencing, cell cycle progression, and DNA replication.

doi:10.1091/mbc.6.6.741

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Article

The origin recognition complex in silencing, cell cycle progression, and DNA replication.

Molecular biology of the cell - 1 Jun 1995

Loo S, Fox C A, Rine J, Kobayashi R, Stillman B, Bell S

Abstract excerpt

This report describes the isolation of ORC5, the gene encoding the fifth largest subunit of the origin recognition complex, and the properties of mutants with a defective allele of ORC5. The orc5-1 mutation caused temperature-sensitive growth and, at the restrictive temperature, caused cell cycle...

Topics

Amino Acid Sequence
Base Sequence
Cell Cycle
Cell Cycle Proteins
Cloning, Molecular
Crosses, Genetic
DNA Replication
DNA, Fungal
DNA-Binding Proteins
Genes, Fungal
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Origin Recognition Complex

Phenotype

Plasmids

Polymerase Chain Reaction

Repressor Proteins

Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 7579692
DOI: 10.1091/mbc.6.6.741
PMCID: PMC301233

Genes

ORC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7579692-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The origin recognition complex in silencing, cell cycle progression, and DNA replication.PMID 7579692Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Yeast origin recognition complex functions in transcription silencing and DNA replication.Semantic proximity Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.Semantic proximity Read ↗

Analysis on origin recognition complex containing Orc5p with defective Walker A motif.Semantic proximity Read ↗

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.Semantic proximity Read ↗

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.Semantic proximity Read ↗

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

ATP bound to the origin recognition complex is important for preRC formation.Semantic proximity Read ↗

Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.Semantic proximity Read ↗

Studies of the properties of human origin recognition complex and its Walker A motif mutants.Semantic proximity Read ↗

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