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Article

The origin recognition complex in silencing, cell cycle progression, and DNA replication.

Molecular biology of the cell - 1 Jun 1995

Loo S, Fox C A, Rine J, Kobayashi R, Stillman B, Bell S

Abstract excerpt

This report describes the isolation of ORC5, the gene encoding the fifth largest subunit of the origin recognition complex, and the properties of mutants with a defective allele of ORC5. The orc5-1 mutation caused temperature-sensitive growth and, at the restrictive temperature, caused cell cycle arrest. At the permissive temperature, the orc5-1 mutation caused an elevated plasmid loss rate that could be...

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Identifiers

PMID: 7579692
DOI: 10.1091/mbc.6.6.741
PMCID: PMC301233

Genes

ORC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The origin recognition complex in silencing, cell cycle progression, and DNA replication.PMID 7579692Read ↗

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

Yeast origin recognition complex functions in transcription silencing and DNA replication.Semantic proximity Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.Semantic proximity Read ↗

Analysis on origin recognition complex containing Orc5p with defective Walker A motif.Semantic proximity Read ↗

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.Semantic proximity Read ↗

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.Semantic proximity Read ↗

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

Roles for ORC in M phase and S phase.Semantic proximity Read ↗

ATP bound to the origin recognition complex is important for preRC formation.Semantic proximity Read ↗

Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells.Semantic proximity Read ↗

Studies of the properties of human origin recognition complex and its Walker A motif mutants.Semantic proximity Read ↗

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