Article
CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1992
Chen Y, Hennessy K M, Botstein D, Tye B K
Abstract excerpt
Saccharomyces cerevisiae cells containing mutations in the cell-division-cycle gene CDC46 arrest with a large bud and a single nucleus with unreplicated DNA at the non-permissive temperature. This G1/S arrest, together with the increased rates of mitotic chromosome loss and recombination phenotype, suggests that these mutants are defective in DNA replication. The subcellular localization of the CDC46 protein...
Topics
- Amino Acid Sequence
- Cell Cycle
- Cell Cycle Proteins
- Cell Division
- Chromosomes, Fungal
- DNA Replication
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- Genotype