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Article

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997

Hardy C F, Dryga O, Seematter S, Pahl P M, Sclafani R A

Abstract excerpt

Cdc7p is a protein kinase that is required for G1/S transition and initiation of DNA replication in Saccharomyces cerevisiae. The mechanisms whereby Cdc7p and its substrates exerts their effects are unknown. We report here the characterization in S. cerevisiae of a recessive mutation in a member of the MCM family, MCM5/CDC46, which bypasses the requirement for Cdc7p and its interacting factor Dbf4p. Because the...

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Source

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Identifiers

PMID: 9096361
DOI: 10.1073/pnas.94.7.3151
PMCID: PMC20337

Genes

MCM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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