Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Cdc45p, an essential factor required for DNA replication.

Gene - 18 Mar 1997

Hardy C F

Abstract excerpt

CDC45 is an essential gene required for initiation of DNA replication in the budding yeast Saccharomyces cerevisiae. CDC45 interacts genetically with CDC46 and CDC47, both members of the MCM family of genes which have been implicated in the licensing of DNA replication. In this report, the isolation of CDC45 is described. The complementing gene is linked to an essential open reading frame on chromosome XII. CDC45...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Fungal Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Source

Identifiers

PMID: 9099887
DOI: 10.1016/s0378-1119(96)00761-5

Genes

CDC45
MCM3
ORC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Cdc45p, an essential factor required for DNA replication.PMID 9099887Read ↗

CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication.Semantic proximity Read ↗

SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast.Semantic proximity Read ↗

DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p.Semantic proximity Read ↗

The effects of <i>CDC45</i> mutations on DNA replication and genome stabilitySemantic proximity Read ↗

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae.Semantic proximity Read ↗

The essential schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene.Semantic proximity Read ↗

Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.Semantic proximity Read ↗

DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in <i>Leishmania donovani</i> and the Cdc45 PIP box is essential for cell survivalSemantic proximity Read ↗

Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.Semantic proximity Read ↗

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.Semantic proximity Read ↗

A CDC45 homolog in Arabidopsis is essential for meiosis, as shown by RNA interference-induced gene silencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.