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Article

Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae.

Journal of molecular biology - 2 Jul 2004

Sawyer Sara L, Cheng Irene H, Chai Weihang, Tye Bik K

Abstract excerpt

Mcm10 has recently been found to play a crucial role in multiple steps of the DNA replication initiation process in eukaryotes. Here, we have examined the role of Mcm10 in assembling initiation factors at a well-characterized yeast replication origin, ARS1. We find that the pre-replication complex (pre-RC) components Cdc6 and Mcm7 associate with ARS1 in the mcm10-1 mutant, suggesting that establishment of the...

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Identifiers

PMID: 15201046
DOI: 10.1016/j.jmb.2004.04.066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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