A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.

doi:10.1128/MCB.17.6.3261

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Article

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jun 1997

Merchant A M, Kawasaki Y, Chen Y, Lei M, Tye B K

Abstract excerpt

We describe a new minichromosome maintenance factor, Mcm10, and show that this essential protein is involved in the initiation of DNA replication in Saccharomyces cerevisiae. The mcm10 mutant has an autonomously replicating sequence-specific minichromosome maintenance defect and arrests at the no...

Topics

Alleles
Cell Cycle
Cell Cycle Proteins
Cell Division
Cell Nucleus
Chromosomal Proteins, Non-Histone
Cloning, Molecular
DNA Replication
DNA, Fungal
Fungal Proteins
Minichromosome Maintenance Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Nucleic Acid Conformation

Phenotype

Plasmids

Replication Origin

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9154825
DOI: 10.1128/MCB.17.6.3261
PMCID: PMC232179

Genes

MCM10
MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9154825-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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