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Article

Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.

Genes & development - 1 Nov 1993

Yan H, Merchant A M, Tye B K

Abstract excerpt

MCM2 and MCM3 are two genetically interacting and structurally related proteins essential for growth in Saccharomyces cerevisiae. Mutants defective in these proteins affect the stability of minichromosomes in general, but the severity of the defect is dependent on the autonomously replicating sequence (ARS) that drives the replication of that plasmid. In this paper we show by two-dimensional gel electrophoresis...

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Source

Identifiers

PMID: 8224843
DOI: 10.1101/gad.7.11.2149

Genes

MCM2
MCM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.PMID 8224843Read ↗

A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.Semantic proximity Read ↗

The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication.Semantic proximity Read ↗

The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.Semantic proximity Read ↗

The role of the carboxyterminal domain of RNA polymerase II in regulating origins of DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.Semantic proximity Read ↗

Two steps in the assembly of complexes at yeast replication origins in vivo.Semantic proximity Read ↗

Chromosomal Mcm2-7 distribution is the primary driver of the genome replication program in species from yeast to humansSemantic proximity Read ↗

Mcm10 mediates the interaction between DNA replication and silencing machineries.Semantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cellsSemantic proximity Read ↗

Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patternsSemantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

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