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Article

Frequent p53 mutations in head and neck cancer.

Cancer research - 1 Nov 1992

Somers K D, Merrick M A, Lopez M E, Incognito L S, Schechter G L, Casey G

Abstract excerpt

Squamous cell carcinomas of the head and neck (SCCHN) are associated strongly with the use of tobacco and alcohol, but little is known about the molecular pathogenesis of these tumors. In the present study, we analyzed SCCHN for mutations in the tumor suppressor gene p53 by immunocytochemistry an...

Topics

Adult
Aged
Aged, 80 and over
Amino Acid Sequence
Carcinoma, Squamous Cell
Female
Genes, p53
Head and Neck Neoplasms
Humans
Immunohistochemistry
Male
Middle Aged
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 1394225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1394225-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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