Article
Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck.
The New England journal of medicine - 16 Mar 1995
Brennan J A, Boyle J O, Koch W M, Goodman S N, Hruban R H, Eby Y J, Couch M J, Forastiere A A, Sidransky D
Abstract excerpt
BACKGROUND: Although epidemiologic studies have long associated tobacco and alcohol use with the development of squamous-cell carcinoma of the head and neck, the molecular targets of these carcinogens have yet to be identified. We performed a molecular analysis to determine the pattern of mutatio...
Topics
- Base Composition
- Carcinoma, Squamous Cell
- Confidence Intervals
- Conserved Sequence
- DNA Mutational Analysis
- Female
- Frameshift Mutation
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged
- Mutation
- Sequence Analysis
- Smoking