Article
Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck.
The New England journal of medicine - 16 Mar 1995
Brennan J A, Boyle J O, Koch W M, Goodman S N, Hruban R H, Eby Y J, Couch M J, Forastiere A A, Sidransky D
Abstract excerpt
BACKGROUND: Although epidemiologic studies have long associated tobacco and alcohol use with the development of squamous-cell carcinoma of the head and neck, the molecular targets of these carcinogens have yet to be identified. We performed a molecular analysis to determine the pattern of mutations in the p53 gene in neoplasms from patients with squamous-cell carcinoma of the head and neck and a history of...
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